The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data.

ABSTRACT: Xanthohumol is a prenylated chalcone, which is mainly found in hops. Experimental studies show a variety of cardioprotective effects for xanthohumol, but so far there are only a few controlled studies on the bioavailability and efficacy of xanthohumol in humans. In a randomized crossover bioavailability trial, the plasma kinetics of 86 mg and 172 mg each of micellar or native xanthohumol were investigated. Blood samples were obtained at fasting (t₀), regularly until 9 h and 24 h after oral xanthohumol bolus administration and the plasma concentrations of xanthohumol, xanthohumol glucuronide, and xanthohumol sulfate were analyzed. Micellation increased the area under the plasma concentration-time curve (AUC) (p < 0.001) and maximum plasma concentration (p <0.001). Both formulatio

SUBMITTER: Brehmer-Henkel S 

PROVIDER: S-EPMC12925386 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature