TGF-β signaling mediates crosstalk between CD8⁺ T cells and CD39⁺ induced Treg cells in autoimmune inflammation.

ABSTRACT:

Background

Autoimmune inflammation results from dysregulated immune responses, with dysfunction of regulatory T cells (Tregs) being a key contributor due to their critical role in maintaining immune tolerance. The stability and function of Tregs are strongly influenced by the inflammatory microenvironment, yet the regulatory interactions between CD8⁺ T cells and CD4⁺Foxp3⁺ Tregs remain poorly understood.

Methods

We investigated the role of CD8⁺ T cells in regulating induced Tregs (iTregs) using in vitro T cell co-culture assays and two in vivo models of autoimmune disease. A naïve CD4⁺ T cell transfer colitis model was used to evaluate the suppressive function of iTregs in the presence or absence of CD8⁺ T cel

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12933926 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature