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A one-step chemical derivatization strategy for mass spectrometric characterization of synthetic mimetics of sulfated glycosaminoglycans.

ABSTRACT: We present a novel one-step methodology for direct mass spectrometric characterization of sulfated non-saccharide glycosaminoglycan mimetics in their sodiated form using the high reactivity of trifluorodiazoethane to form hydrophobic and chemically stable esters that facilitates separation and detection in a liquid chromatography-mass spectrometry system. The methodology preserves all sulfates present in the parent molecule, thereby allowing for accurate mass characterization of the per-sulfated molecule.

SUBMITTER: Sharma C 

PROVIDER: S-EPMC12934201 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature

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A one-step chemical derivatization strategy for mass spectrometric characterization of synthetic mimetics of sulfated glycosaminoglycans.

Sharma Chiranjeev C   Afosah Daniel K DK   Villuri Bharath K BK   Desai Umesh R UR  

Analytical methods : advancing methods and applications 20260305 9

We present a novel one-step methodology for direct mass spectrometric characterization of sulfated non-saccharide glycosaminoglycan mimetics in their sodiated form using the high reactivity of trifluorodiazoethane to form hydrophobic and chemically stable esters that facilitates separation and detection in a liquid chromatography-mass spectrometry system. The methodology preserves all sulfates present in the parent molecule, thereby allowing for accurate mass characterization of the per-sulfated  ...[more]

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