From Gas Chromatography-Mass Spectrometry (GC-MS) to Network Pharmacology: System-Level Insights into the Multi-Target Biological Potential of <i>Flaveria trinervia</i> (Spreng.) C. Mohr.

ABSTRACT: Flaveria trinervia (Spreng) C. Mohr is a plant traditionally used in Mexican medicine. In this study, gas chromatography-mass spectrometry (GC-MS) combined with network pharmacology was employed to characterize volatile and semi-volatile metabolites from F. trinervia leaves and to explore their potential system-level mechanisms of action in inflammatory and tumor-related disorders. A dual extraction strategy (hexane/dichloromethane and acetone/chloroform) was applied, followed by GC-MS-based compound identification. Putative molecular targets were predicted using established pharmacological databases, and protein-protein interaction networks were constructed to identify topological features and enriched biological pathways. A total of 11 bioactive compounds were tentatively i

SUBMITTER: Torres Flores C 

PROVIDER: S-EPMC12939618 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature