Exercise alveolar oxygen extraction rate reflects ventilatory efficiency and predicts outcomes in idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Oxygen uptake (V'_O2) obtained from expiratory gas analysis is generally calculated using minute ventilation (V'_E) and the inspired‒expired mean oxygen (O₂) concentration difference (ΔF_O2) during cardiopulmonary exercise testing (CPET). We have reported that ΔF_O2, which is associated with ventilatory efficiency, is independent of V'_E at peak exercise and affects exercise tolerance in respiratory diseases other than idiopathic pulmonary fibrosis (IPF). We hypothesized that similar results are obtained in IPF, and that ΔF_O2 is a prognostic factor for survival in IPF.

Methods

Forty-three patients with IPF, who underwent CPET with blood gas analysis were enrolled from our database.

Results<

SUBMITTER: Miki K 

PROVIDER: S-EPMC12947475 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature