Pro-Inflammatory Cytokines in Aqueous Humor From ADAMTS10-Mutant Beagles at an Early Stage of Open-Angle Glaucoma.

ABSTRACT:

Objective

To investigate the level of pro-inflammatory cytokines in aqueous humor from ADAMTS10-mutant research Beagles at an early stage of open-angle glaucoma (OAG).

Animals studied

Twenty-four research Beagles were enrolled into this case-controlled study. Three groups of ADAMTS10-mutant research Beagles were enrolled in this study: (1) Intraocular pressure (IOP) 15-25 mmHg (normotensive IOP), (2) IOP 25-30 mmHg, and (3) IOP 30-36 mmHg. An unaffected control group of Beagles that were either ADAMTS10-wildtype (WT) or heterozygote-carrier with normotensive IOPs were also enrolled.

Procedures

Aqueous humor samples were collected and analyzed for 16 pro-inflammatory cytokines using the Canine Cytokine SpikeMix and target mass spectrometry via multiple reaction monitor

SUBMITTER: Collins E 

PROVIDER: S-EPMC12949407 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature