Efficient asymmetric synthesis of (+)-SCH 351448.

ABSTRACT: An efficient and stereocontrolled total synthesis of (+)-SCH 351448, a novel activator of low-density lipoprotein receptor promoter, has been achieved with a longest linear sequence of 21 steps. Key steps include applications of the recently developed asymmetric allyl- and crotylsilane reagents and a new protodesilylative version of the tandem silylformylation/allylsilylation reaction, which provides an efficient synthesis of 1,5-syn-diols. [reaction: see text]

SUBMITTER: Bolshakov S 

PROVIDER: S-EPMC1393291 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature