Feasibility of an HA2 domain-based periodontitis vaccine.

ABSTRACT: In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.

SUBMITTER: DeCarlo AA 

PROVIDER: S-EPMC143394 | biostudies-literature | 2003 Jan

REPOSITORIES: biostudies-literature