Wiring optimization can relate neuronal structure and function.
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ABSTRACT:
SUBMITTER: Chen BL
PROVIDER: S-EPMC1550972 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Wiring optimization can relate neuronal structure and function.
Chen Beth L BL Hall David H DH Chklovskii Dmitri B DB
Proceedings of the National Academy of Sciences of the United States of America 20060314 12
We pursue the hypothesis that neuronal placement in animals minimizes wiring costs for given functional constraints, as specified by synaptic connectivity. Using a newly compiled version of the Caenorhabditis elegans wiring diagram, we solve for the optimal layout of 279 nonpharyngeal neurons. In the optimal layout, most neurons are located close to their actual positions, suggesting that wiring minimization is an important factor. Yet some neurons exhibit strong deviations from "optimal" positi ...[more]
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