Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model.

ABSTRACT: Using a purpose-designed experimental model, we have defined new, statistically significant, differences in gene expression between heavily and weakly metastatic human breast cancer cell populations, in vivo and in vitro. The differences increased under selection pressures designed to increase metastatic proficiency. Conversely, the expression signatures of primary tumors generated by more aggressive variants, and their matched metastases in the lungs and lymph nodes, all tended to converge. However, the few persisting differences among these selectively enriched malignant growths in the breast, lungs, and lymph nodes were highly statistically significant, implying potential mechanistic involvement of the corresponding genes. The evidence that has emerged from the current work indicates th

SUBMITTER: Montel V 

PROVIDER: S-EPMC1606408 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature