Ontology highlight
ABSTRACT:
SUBMITTER: Valls E
PROVIDER: S-EPMC162251 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Valls Ester E de la Cruz Xavier X Martínez-Balbás Marian A MA
Nucleic acids research 20030601 12
Histone acetyltransferases (HATs) play a key role in transcription control, cell proliferation and differentiation by modulating chromatin structure; however, little is known about their own regulation. Here we show that expression of the viral oncoprotein SV40 T antigen increases histone acetylation and global cellular HAT activities. In addition, it enhances CREB-binding protein HAT activity and modulates its transcriptional activity. Finally, we show that inhibition of cellular histone deacet ...[more]