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The SV40 T antigen modulates CBP histone acetyltransferase activity.


ABSTRACT: Histone acetyltransferases (HATs) play a key role in transcription control, cell proliferation and differentiation by modulating chromatin structure; however, little is known about their own regulation. Here we show that expression of the viral oncoprotein SV40 T antigen increases histone acetylation and global cellular HAT activities. In addition, it enhances CREB-binding protein HAT activity and modulates its transcriptional activity. Finally, we show that inhibition of cellular histone deacetylases by trichostatin A increases the SV40 infectivity rate. These findings highlight the importance of histone acetylation in the regulation of the cell cycle by oncoviral proteins.

SUBMITTER: Valls E 

PROVIDER: S-EPMC162251 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature

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The SV40 T antigen modulates CBP histone acetyltransferase activity.

Valls Ester E   de la Cruz Xavier X   Martínez-Balbás Marian A MA  

Nucleic acids research 20030601 12


Histone acetyltransferases (HATs) play a key role in transcription control, cell proliferation and differentiation by modulating chromatin structure; however, little is known about their own regulation. Here we show that expression of the viral oncoprotein SV40 T antigen increases histone acetylation and global cellular HAT activities. In addition, it enhances CREB-binding protein HAT activity and modulates its transcriptional activity. Finally, we show that inhibition of cellular histone deacet  ...[more]

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