MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males.

ABSTRACT: AIMS:A noncoding single nucleotide polymorphism (SNP) in exon 26 3435C > T of the highly polymorphic MDR1 gene has been demonstrated to alter digoxin absorption after induction of the MDR1 gene product P-glycoprotein by rifampicin or after multiple oral dosing. The aim of the study was to investigate the effects of the major known MDR1 SNPs on the absorption of digoxin after a single oral dose in a large sample without drug pretreatment. METHODS:Fifty healthy white male subjects between the age of 18 and 40 years were enrolled. Following an overnight fast, all subjects received a single oral dose of 1 mg digoxin. Venous blood samples were taken at intervals up to 4 h post dose to obtain a pharmacokinetic profile. RESULTS:AUC(0,4 h), Cmax and tmax, used as indices of digoxin absorption, wer

SUBMITTER: Gerloff T 

PROVIDER: S-EPMC1874502 | biostudies-literature | 2002 Dec

REPOSITORIES: biostudies-literature