Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor.

ABSTRACT:

Background

Ovarian folliculogenesis in mammals is a complex process involving interactions between germ and somatic cells. Carefully orchestrated expression of transcription factors, cell adhesion molecules and growth factors are required for success. We have identified a germ-cell specific, basic helix-loop-helix transcription factor, FIGLA (Factor In the GermLine, Alpha) and demonstrated its involvement in two independent developmental processes: formation of the primordial follicle and coordinate expression of zona pellucida genes.

Results

Taking advantage of Figla null mouse lines, we have used a combined approach of microarray and Serial Analysis of Gene Expression (SAGE) to identify potential downstream target genes. Using high stringent cutoffs, we find that FIGLA fun

SUBMITTER: Joshi S 

PROVIDER: S-EPMC1906760 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature