Ontology highlight
ABSTRACT:
SUBMITTER: Fujimoto W
PROVIDER: S-EPMC1976593 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Fujimoto Wakako W Shiuchi Tetsuya T Miki Takashi T Minokoshi Yasuhiko Y Takahashi Yoshihisa Y Takeuchi Ayako A Kimura Kazuhiro K Saito Masayuki M Iwanaga Toshihiko T Seino Susumu S
Proceedings of the National Academy of Sciences of the United States of America 20070914 39
Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1(-/-) mouse from its cohabitants induces self-starvation, sometimes leading to death, features similar to those of anorexia nervosa in humans. Interestingly, overexpression of agouti in Dmbx1(-/-) mice failed to induce aspects of the A(y)/a phenotype, including hyperphagia, obesity, and diabetes melli ...[more]