Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia.

ABSTRACT:

Background

Schizophrenia is characterized by complex gene expression changes. The transcriptome alterations in the prefrontal cortex have been the subject of several recent postmortem studies that yielded both convergent and divergent findings.

Methods

To increase measurement precision, we used a custom-designed DNA microarray platform with long oligonucleotides and multiple probes with replicates. The platform was designed to assess the expression of > 1800 genes specifically chosen because of their hypothesized roles in the pathophysiology of schizophrenia. The gene expression differences in dorsolateral prefrontal cortex samples from 14 matched pairs of schizophrenia and control subjects were analyzed with two technical replicates and four data mining approaches.

Resul

SUBMITTER: Arion D 

PROVIDER: S-EPMC2080683 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature