Enhancement of muscle mitochondrial function by growth hormone.

ABSTRACT:

Context

Although GH promotes growth and protein anabolism, which are ATP-dependent processes, the GH effect on mitochondrial regulation remains to be determined.

Objective

Our objective was to determine the acute effect of GH on mitochondrial oxidative capacity in skeletal muscle of healthy subjects.

Design and setting

The study was a randomized crossover design at an academic medical center.

Participants

Nine healthy men and women completed the study.

Intervention

GH (150 microg/h) or saline was infused for 14 h on separate days, and muscle biopsies were obtained.

Main outcome measures

Outcome measures included mitochondrial function, gene expression, and protein metabolism.

Results

The 4-fold increase in plasma GH caused elevations in pla

SUBMITTER: Short KR 

PROVIDER: S-EPMC2243230 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature