Pesticide exposure and risk of Parkinson's disease: a family-based case-control study.

ABSTRACT:

Background

Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but few family-based studies have examined these relationships.

Methods

Using 319 cases and 296 relative and other controls, associations of direct pesticide application, well-water consumption, and farming residences/occupations with PD were examined using generalized estimating equations while controlling for age-at-examination, sex, cigarette smoking, and caffeine consumption.

Results

Overall, individuals with PD were significantly more likely to report direct pesticide application than their unaffected relatives (odds ratio = 1.61; 95% confidence interval, 1.13-2.29). Frequency, duration, and cumulativ

SUBMITTER: Hancock DB 

PROVIDER: S-EPMC2323015 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature