Aggressive and non-aggressive personalities differ in oxidative status in selected lines of mice (Mus musculus).

ABSTRACT: Mice selected for aggression and coping (long attack latency (LAL), reactive coping strategy; short attack latency (SAL), pro-active coping strategy) are a useful model for studying the physiological background of animal personalities. These mice also show a differential stress responsiveness, especially in terms of hypothalamic-pituitary-adrenal axis reactivity, to various challenges. Since the stress response can increase the production of reactive oxygen species, we predicted that the basic oxidative status of the lines could differ. We found that LAL showed higher serum antioxidant capacity (OXY) than SAL, while no differences emerged for reactive oxygen metabolites (ROMs) or the balance between ROMs and OXY, reflecting oxidative stress. Moreover, the lines showed inverse relationships

SUBMITTER: Costantini D 

PROVIDER: S-EPMC2412938 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature