Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development.

ABSTRACT: Chromatin remodeling complexes control the availability of DNA binding sites to transcriptional regulators. Two distinct conserved forms of the SWI/SNF class of complexes are characterized by the presence of specific accessory subunits. In Drosophila, the core Brahma complex associates either with Osa to form the BAP complex or with Bap170 and Bap180 to form the PBAP complex. osa mutations reproduce only a subset of the developmental phenotypes caused by mutations in subunits of the core complex. To test whether the PBAP complex performs the remaining functions, we generated mutations in bap170 and bap180. Surprisingly, we found that Bap180 is not essential for viability, although it is required in ovarian follicle cells for normal eggshell development. Bap170 is necessary to stabilize the

SUBMITTER: Carrera I 

PROVIDER: S-EPMC2519717 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature