Antioxidant intervention of smoking-induced lung tumor in mice by vitamin E and quercetin.

ABSTRACT:

Background

Epidemiological and in vitro studies suggest that antioxidants such as quercetin and vitamin E (VE) can prevent lung tumor caused by smoking; however, there is limited evidence from animal studies.

Methods

In the present study, Swiss mouse was used to examine the potential of quercetin and VE for prevention lung tumor induced by smoking.

Results

Our results suggest that the incidence of lung tumor and tumor multiplicity were 43.5% and 1.00 +/- 0.29 in smoking group; Quercetin has limited effects on lung tumor prevention in this in vivo model, as measured by assays for free radical scavenging, reduction of smoke-induced DNA damage and inhibition of apoptosis. On the other hand, vitamin E drastically decreased the incidence of lung tumor and tumor multiplicit

SUBMITTER: Yang J 

PROVIDER: S-EPMC2625366 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature