Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN.

ABSTRACT:

Objective

To compare patterns of gray matter loss in subjects with mutations in the progranulin (PGRN) gene to subjects with mutations in the microtubule-associated protein tau (MAPT) gene.

Methods

We identified all subjects seen at the Mayo Clinic, Rochester, MN, who had screened positive for mutations in PGRN or MAPT and had a head MRI. Twelve cases with mutations in the PGRN gene were matched by time from disease onset to scan to 12 subjects with mutations in the MAPT gene. Voxel-based morphometry was used to assess patterns of gray matter loss in the PGRN and MAPT groups compared to a control cohort, and compared to each other. MAPT subjects were younger than the PGRN subjects; therefore, each group was also compared to a specific age-matched control group.

Results

SUBMITTER: Whitwell JL 

PROVIDER: S-EPMC2677544 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature