Contribution of Bordetella bronchiseptica filamentous hemagglutinin and pertactin to respiratory disease in swine.

ABSTRACT: Bordetella bronchiseptica is pervasive in swine populations and plays multiple roles in respiratory disease. Most studies addressing virulence factors of B. bronchiseptica are based on isolates derived from hosts other than pigs. Two well-studied virulence factors implicated in the adhesion process are filamentous hemagglutinin (FHA) and pertactin (PRN). We hypothesized that both FHA and PRN would serve critical roles in the adhesion process and be necessary for colonization of the swine respiratory tract. To investigate the role of FHA and PRN in Bordetella pathogenesis in swine, we constructed mutants containing an in-frame deletion of the FHA or the PRN structural gene in a virulent B. bronchiseptica swine isolate. Both mutants were compared to the wild-type swine isolate for their abil

SUBMITTER: Nicholson TL 

PROVIDER: S-EPMC2681739 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature