The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock.

ABSTRACT:

Background

Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock. Here we present novel activities for PAF in protecting mice against LPS-mediated endotoxic shock.

Principal findings

In vivo PAF treatment immediately after LPS challenge markedly improved the survival rate against mortality from endotoxic shock. Administration of PAF prominently attenuated LPS-induced organ injury, including profound hypotension, excessive polymorphonuclear neutrophil infiltration, and severe multiple organ failure. In addition, PAF treatment protects against LPS-induced lymphocytes apoptosis. These protective effects of PAF was correlated with significantly decreases in the production of the inflammatory mediators

SUBMITTER: Jeong YI 

PROVIDER: S-EPMC2714981 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature