Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis.

ABSTRACT:

Rationale

Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown.

Objectives

To investigate whether persistent inflammation, defined as elevating circulating inflammatory markers at hospital discharge, is associated with subsequent outcomes.

Methods

Prospective cohort study at 28 sites.

Measurements and main results

We used standard criteria to define CAP and the National Death Index to determine all-cause and cause-specific 1-year mortality. At hospital discharge, 1,799 subjects (77.5%) were alive and vital signs had returned to normal in 1,512 (87%) subjects. The geometric means (+/-SD) for circulating IL-6 and IL-10 conce

SUBMITTER: Yende S 

PROVIDER: S-EPMC2720087 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature