Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach.

ABSTRACT:

Background

Recent data have implicated telomere length shortening as a potential risk predictor for cardiovascular disease. However, to date, prospective epidemiological data are scarce.

Methods

Using leukocyte DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the relationship of mean telomere repeat copy number to single gene copy number (T/S ratio), using a re-modified quantitative polymerase chain reaction protocol, among 337 white males who subsequently developed an incident myocardial infarction (MI), and among an equal number of age- and smoking-matched white males who remained free of reported vascular disease during follow-up (controls).

Results

The mean follow-up time since randomization was 3.85 y

SUBMITTER: Zee RY 

PROVIDER: S-EPMC2752372 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature