Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone.

ABSTRACT:

Objective

The goal of this pilot study was to evaluate the effects of testosterone (T) cotherapy on mammary gland and endometrial measures in a postmenopausal primate model.

Methods

Twenty-five surgically postmenopausal cynomolgus monkeys were randomized by social group to receive daily treatment with (1) placebo, (2) oral micronized 17beta-estradiol (1 mg/d equivalent in women) + progesterone (200 mg/d equivalent in women) (E + P), or (3) E + P with T administered via subcutaneous pellets for 8 weeks at a high dose (15 mg) followed by 8 weeks at a low dose (1.5 mg) (E + P + T). The main outcome measures were breast and endometrial epithelial proliferation, as measured by Ki67/MIB1 immunolabeling.

Results

Intralobular breast proliferation did not differ significantly

SUBMITTER: Wood CE 

PROVIDER: S-EPMC2755604 | biostudies-literature | 2009 May-Jun

REPOSITORIES: biostudies-literature