Dataset Information

Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone.

ABSTRACT:

Objective

The goal of this pilot study was to evaluate the effects of testosterone (T) cotherapy on mammary gland and endometrial measures in a postmenopausal primate model.

Methods

Twenty-five surgically postmenopausal cynomolgus monkeys were randomized by social group to receive daily treatment with (1) placebo, (2) oral micronized 17beta-estradiol (1 mg/d equivalent in women) + progesterone (200 mg/d equivalent in women) (E + P), or (3) E + P with T administered via subcutaneous pellets for 8 weeks at a high dose (15 mg) followed by 8 weeks at a low dose (1.5 mg) (E + P + T). The main outcome measures were breast and endometrial epithelial proliferation, as measured by Ki67/MIB1 immunolabeling.

Results

Intralobular breast proliferation did not differ significantly among groups after 8 weeks of treatment but was marginally higher (P = 0.03) in the E + P + T group after 16 weeks of treatment. No significant increase in proliferation was seen for E + P alone. Comparable changes in mammary gland markers of estrogen-receptor activity were seen for the E + P and E + P + T groups. In the endometrium, the addition of T did not increase endometrial glandular proliferation or estrogen-receptor activity or result in any distinct histologic changes.

Conclusions

The findings of this study do not support the idea that T antagonizes the effects of combined hormone therapy on breast proliferation or markers of estrogen-receptor activity. Overall, the short-term effects of T cotherapy on the mammary gland and endometrium were minimal.

SUBMITTER: Wood CE

PROVIDER: S-EPMC2755604 | biostudies-literature | 2009 May-Jun

REPOSITORIES: biostudies-literature

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Publications

Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone.

Wood Charles E CE Lees Cynthia J CJ Cline J Mark JM

Menopause (New York, N.Y.) 20090501 3

<h4>Objective</h4>The goal of this pilot study was to evaluate the effects of testosterone (T) cotherapy on mammary gland and endometrial measures in a postmenopausal primate model.<h4>Methods</h4>Twenty-five surgically postmenopausal cynomolgus monkeys were randomized by social group to receive daily treatment with (1) placebo, (2) oral micronized 17beta-estradiol (1 mg/d equivalent in women) + progesterone (200 mg/d equivalent in women) (E + P), or (3) E + P with T administered via subcutaneou ...[more]

PMID: 19265727

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Dataset Information

Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone.

Objective

Methods

Results

Conclusions

Publications

Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone.

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