Intrapartum antibiotic exposure and early neonatal, morbidity, and mortality in Africa.

ABSTRACT:

Background

Infants born to women who receive intrapartum antibiotics may have higher rates of infectious morbidity and mortality than unexposed infants.

Objective

Our goal was to determine the association of maternal intrapartum antibiotics and early neonatal morbidity and mortality.

Methods

We performed secondary analysis of data from a multisite randomized, placebo-controlled clinical trial of antibiotics to prevent chorioamnionitis-associated mother-to-child transmission of HIV-1 and preterm birth in sub-Saharan Africa. Early neonatal morbidity and mortality were analyzed. In an intention-to-treat (ITT) analysis, infants born to women randomly assigned to antibiotics or placebo were compared. In addition, non-ITT analysis was performed because some women received n

SUBMITTER: Kafulafula G 

PROVIDER: S-EPMC2764263 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature