Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma.

ABSTRACT:

Purpose

To determine whether the polymorphisms of calcitonin receptor-like receptor gene (CALCRL) are associated with primary angle closure glaucoma (PACG) in a southern Chinese population.

Methods

A total of 207 individuals with acute and chronic PACG and 205 ethnically matched controls were recruited in the current study. A tag-single nucleotide polymorphism approach was used to investigate this gene. Alleles were determined by PCR restriction fragment length polymorphism.

Results

The results show a nominal association between rs1157699 and acute PACG (uncorrected p=0.024 and 0.028 for alleles and genotypes, respectively). Haplotype T(rs840617)C(rs6759535)T(rs1157699) frequency is significantly higher in acute PACG patients than in controls (corrected p=0.012), wher

SUBMITTER: Cao D 

PROVIDER: S-EPMC2773738 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature