Dataset Information

Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain.

ABSTRACT:

Background

In this paper we explored thalamocortical functional connectivity in a group of eight patients suffering from peripheral neuropathic pain (diabetic pain), and compared it with that of a group of healthy subjects. We hypothesized that functional interconnections between the thalamus and cortex can be altered after years of ongoing chronic neuropathic pain.

Results

Functional connectivity was studied through a resting state functional magnetic resonance imaging (fMRI) paradigm: temporal correlations between predefined regions of interest (primary somatosensory cortex, ventral posterior lateral thalamic nucleus, medial dorsal thalamic nucleus) and the rest of the brain were systematically investigated. The patient group showed decreased resting state functional connectivity between the thalamus and the cortex.

Conclusion

This supports the idea that chronic pain can alter thalamocortical connections causing a disruption of thalamic feedback, and the view of chronic pain as a thalamocortical dysrhythmia.

SUBMITTER: Cauda F

PROVIDER: S-EPMC2789078 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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Publications

Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain.

Cauda Franco F Sacco Katiuscia K D'Agata Federico F Duca Sergio S Cocito Dario D Geminiani Giuliano G Migliorati Filippo F Isoardo Gianluca G

BMC neuroscience 20091126

<h4>Background</h4>In this paper we explored thalamocortical functional connectivity in a group of eight patients suffering from peripheral neuropathic pain (diabetic pain), and compared it with that of a group of healthy subjects. We hypothesized that functional interconnections between the thalamus and cortex can be altered after years of ongoing chronic neuropathic pain.<h4>Results</h4>Functional connectivity was studied through a resting state functional magnetic resonance imaging (fMRI) par ...[more]

PMID: 19941658

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Dataset Information

Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain.

Background

Results

Conclusion

Publications

Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain.

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