Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.

ABSTRACT:

Objective

It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor.

Methods

Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril (n = 347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/deletion polymorphism (Ins/Del): G12269A, C17888T, and G20037A. Time to reach target mean arterial pressure (ResultsIndividuals with a homozygous genotype at G12269A responded significantly faster than those with a heterozygous genotype; the adjusted (

SUBMITTER: Bhatnagar V 

PROVIDER: S-EPMC2792638 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature