Influence of the MTHFR C677T polymorphism on magnetic resonance imaging hyperintensity volume and cognition in geriatric depression.

ABSTRACT:

Objective

The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) has been linked to unipolar major depressive disorder (MDD) and magnetic resonance imaging (MRI) hyperintensities. The authors examined the relationship between the MTHFR C677T polymorphism (C677T) and a) geriatric depression, b) MRI hyperintense lesion volume, and c) neurocognitive test performance.

Design

Cross-sectional.

Setting

Duke University Medical Center.

Participants

Depressed (N = 178) and comparison (N = 85) elderly subjects.

Measurements

Subjects had blood drawn to assess MTHFR genotype, were imaged by MRI to determine their white matter hyperintense lesion (WML) and gray matter hyperintense lesion (GML) volume, and assessed using a comprehensive neurocognitive battery evalua

SUBMITTER: Hong ED 

PROVIDER: S-EPMC2805265 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature