Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis.

ABSTRACT: Schistosomiasis continues to be an important cause of parasitic morbidity and mortality world-wide. Determining the molecular mechanisms regulating the development of granulomas and fibrosis will be essential for understanding how schistosome antigens interact with the host environment. We report here the first whole genome microarray analysis of the murine liver during the progression of Schistosoma japonicum egg-induced granuloma formation and hepatic fibrosis. Our results reveal a distinct temporal relationship between the expression of chemokine subsets and the recruitment of cells to the infected liver. Genes up-regulated earlier in the response included T- and B-cell chemoattractants, reflecting the early recruitment of these cells illustrated by flow cytometry. The later phases of t

SUBMITTER: Burke ML 

PROVIDER: S-EPMC2817718 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature