On finding poorly translated codons based on their usage frequency.
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ABSTRACT:
SUBMITTER: Ponnala L
PROVIDER: S-EPMC2823382 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
On finding poorly translated codons based on their usage frequency.
Bioinformation 20090905 2
Long stretches of "rare" codons are known to severely inhibit the efficiency of translation. Understanding the distribution of such rare codons is of critical importance in improving the efficiency of heterologous gene expression systems. Accurate estimates of codon usage take the abundance of each protein into consideration. In this paper, we analyze the correlation between approximate measures of codon usage and the availability of tRNA at various growth rates in E coli. We show that the compu ...[more]
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