Ontology highlight
ABSTRACT:
SUBMITTER: Butler PL
PROVIDER: S-EPMC2825420 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Butler Phillip L PL Mallampalli Rama K RK
The Journal of biological chemistry 20091215 9
Phosphatidylcholine (PtdCho), the major phospholipid of animal membranes, is generated by its remodeling and de novo synthesis. Overexpression of the remodeling enzyme, LPCAT1 (acyl-CoA:lysophosphatidylcholine acyltransferase) in epithelia decreased de novo PtdCho synthesis without significantly altering cellular PtdCho mass. Overexpression of LPCAT1 increased degradation of CPT1 (cholinephosphotransferase), a resident Golgi enzyme that catalyzes the terminal step for de novo PtdCho synthesis. C ...[more]