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Relationship between coronary endothelial function and coronary calcification in early atherosclerosis.
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ABSTRACT: Background
The relationship between coronary endothelial function and coronary calcification is not well established.Methods
Forty-six patients 17 men [37%]; age, 47.4+/-11.4 years prospectively underwent testing for coronary endothelial function and measurement of coronary artery calcification (CAC).Results
Log CAC scores were not significantly different between patients with normal (n=31) and abnormal (n=15) response of epicardial coronary artery diameter to acetylcholine (%CAD(Ach)) (median (25, 75 percentile) 1.1 (0.0, 3.7) vs. 0.3 (0.0, 2.4), P=.32) and with normal (n=28) and abnormal (n=18) response of coronary blood flow to acetylcholine (%CBF(Ach)) (0.5 (0.0, 3.6) vs. 0.5 (0.0, 3.2), P=.76). Log CAC scores did not correlate with %CAD(Ach) (r=0.08, P=.59), %CBF(Ach) (r=0.14, P=.35).Conclusions
In patients without significant coronary artery disease, coronary endothelial dysfunction showed no apparent association with coronary calcification. Our findings suggest that these 2 markers may represent separate, independent processes in the progression of coronary atherosclerosis.
SUBMITTER: Han SH
PROVIDER: S-EPMC2830342 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Relationship between coronary endothelial function and coronary calcification in early atherosclerosis.
Atherosclerosis 20090821 1
<h4>Background</h4>The relationship between coronary endothelial function and coronary calcification is not well established.<h4>Methods</h4>Forty-six patients 17 men [37%]; age, 47.4+/-11.4 years prospectively underwent testing for coronary endothelial function and measurement of coronary artery calcification (CAC).<h4>Results</h4>Log CAC scores were not significantly different between patients with normal (n=31) and abnormal (n=15) response of epicardial coronary artery diameter to acetylcholi ...[more]
