Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo.

ABSTRACT:

Background

Psoriasis is one of the most frequent skin diseases world-wide. The disease impacts enormously on affected patients and poses a huge financial burden on health care providers. Several lines of evidence suggest that the nuclear hormone receptor peroxisome proliferator activator (PPAR) beta/delta, known to regulate epithelial differentiation and wound healing, contributes to psoriasis pathogenesis. It is unclear, however, whether activation of PPARbeta/delta is sufficient to trigger psoriasis-like changes in vivo.

Methodology/principal findings

Using immunohistochemistry, we define the distribution of PPARbeta/delta in the skin lesions of psoriasis. By expression profiling, we confirm that PPARbeta/delta is overexpressed in the vast majority of psoriasis patients. W

SUBMITTER: Romanowska M 

PROVIDER: S-EPMC2838790 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature