High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer.

ABSTRACT:

Background

This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma.

Methods

First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT-qPCR) experiments, gabarapl1 expression was quantified in several histological breast tumour types and in a retrospective cohort of 265 breast cancers.

Results

GABARAPL1 overexpression inhibited MCF-7 growth rate and gabarapl1 expression was downregulated in breast tumours. Gabarapl1 mRNA levels were found to be significantly lower in tumours presenting a high histological grade, with a lymph node-positive

SUBMITTER: Berthier A 

PROVIDER: S-EPMC2844027 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature