Dataset Information

Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome.

ABSTRACT:

Objective

To investigate the relation between serum concentration of 25-hydroxyvitamin D [25(OH)D] and insulin action and secretion.

Research design and methods

In a cross-sectional study of 446 Pan-European subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry.

Results

The 25(OH)D(3) concentration was 57.1 +/- 26.0 nmol/l (mean +/- SD), and only 20% of the subjects had 25(OH)D(3) levels > or =75 nmol/l. In multiple linear analyses, 25(OH)D(3) concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates.

Conclusions

In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D(3) did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.

SUBMITTER: Gulseth HL

PROVIDER: S-EPMC2845053 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Publications

Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome.

Gulseth Hanne L HL Gjelstad Ingrid M F IM Tierney Audrey C AC Lovegrove Julie A JA Defoort Catherine C Blaak Ellen E EE Lopez-Miranda Jose J Kiec-Wilk Beata B Risérus Ulf U Roche Helen M HM Drevon Christian A CA Birkeland Kåre I KI

Diabetes care 20100112 4

<h4>Objective</h4>To investigate the relation between serum concentration of 25-hydroxyvitamin D [25(OH)D] and insulin action and secretion.<h4>Research design and methods</h4>In a cross-sectional study of 446 Pan-European subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by ...[more]

PMID: 20067973

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Dataset Information

Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome.

Objective

Research design and methods

Results

Conclusions

Publications

Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome.

Similar Datasets

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