Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells.

ABSTRACT:

Background

Wnt-11 is a secreted protein that modulates cell growth, differentiation and morphogenesis during development. We previously reported that Wnt-11 expression is elevated in hormone-independent prostate cancer and that the progression of prostate cancer from androgen-dependent to androgen-independent proliferation correlates with a loss of mutual inhibition between Wnt-11- and androgen receptor-dependent signals. However, the prevalence of increased expression of Wnt-11 in patient tumours and the functions of Wnt-11 in prostate cancer cells were not known.

Results

Wnt-11 protein levels in prostate tumours were determined by immunohistochemical analysis of prostate tumour tissue arrays. Wnt-11 protein was elevated in 77/117 of tumours when compared with 27 benign pro

SUBMITTER: Uysal-Onganer P 

PROVIDER: S-EPMC2846888 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature