Ontology highlight
ABSTRACT:
SUBMITTER: Hopf FW
PROVIDER: S-EPMC2847608 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Neuron 20100301 5
The cellular mechanisms underlying pathological alcohol seeking remain poorly understood. Here, we show an enhancement of nucleus accumbens (NAcb) core action potential firing ex vivo after protracted abstinence from alcohol but not sucrose self-administration. Increased firing is associated with reduced small-conductance calcium-activated potassium channel (SK) currents and decreased SK3 but not SK2 subunit protein expression. Furthermore, SK activation ex vivo produces greater firing suppressi ...[more]