A sequence motif enriched in regions bound by the Drosophila dosage compensation complex.

ABSTRACT:

Background

In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found.

Results

In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the D. melanogaster X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the generation of DCC binding sites and/or the local spreading of the complex. Comparative data indicate

SUBMITTER: Gallach M 

PROVIDER: S-EPMC2848247 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature