Ontology highlight
ABSTRACT:
SUBMITTER: Kuestner RE
PROVIDER: S-EPMC2849293 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20071001 8
The proinflammatory cytokines IL-17A and IL-17F have a high degree of sequence similarity and share many biological properties. Both have been implicated as factors contributing to the progression of inflammatory and autoimmune diseases. Moreover, reagents that neutralize IL-17A significantly ameliorate disease severity in several mouse models of human disease. IL-17A mediates its effects through interaction with its cognate receptor, the IL-17 receptor (IL-17RA). We report here that the IL-17RA ...[more]