Contrasts between adaptive coding and noncoding changes during human evolution.
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ABSTRACT:
SUBMITTER: Haygood R
PROVIDER: S-EPMC2867918 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Contrasts between adaptive coding and noncoding changes during human evolution.
Haygood Ralph R Babbitt Courtney C CC Fedrigo Olivier O Wray Gregory A GA
Proceedings of the National Academy of Sciences of the United States of America 20100412 17
Changes in non-protein-coding regulatory DNA sequences have been proposed to play distinctive roles in adaptive evolution. We analyzed correlations between gene functions and evidence for positive selection in a common statistical framework across several large surveys of coding and noncoding sequences throughout the human genome. Strong correlations with both classifications in gene ontologies and measurements of gene expression indicate that neural development and function have adapted mainly ...[more]
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