How degrading: Cyp26s in hindbrain development.
Ontology highlight
ABSTRACT:
SUBMITTER: White RJ
PROVIDER: S-EPMC2880953 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
How degrading: Cyp26s in hindbrain development.
White Richard J RJ Schilling Thomas F TF
Developmental dynamics : an official publication of the American Association of Anatomists 20081001 10
The vitamin A derivative retinoic acid performs many functions in vertebrate development and is thought to act as a diffusible morphogen that patterns the anterior-posterior axis of the hindbrain. Recent work in several systems has led to insights into how the spatial distribution of retinoic acid is regulated. These have shown local control of synthesis and degradation, and computational models suggest that degradation by the Cyp26 enzymes plays a critical role in the formation of a morphogen g ...[more]
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