Associations of plasma C-peptide and IGFBP-1 levels with risk of colorectal adenoma in a multiethnic population.

ABSTRACT:

Background

Circulating levels of insulin and insulin-like growth factor (IGF) hormones have been associated with colorectal cancer risk, but few studies have examined their associations with colorectal adenoma.

Methods

We measured plasma C-peptide, a marker of insulin secretion, and IGF hormones in a case-control study of 554 pathologically confirmed, first-time adenoma cases and 786 controls with normal endoscopy among Caucasians, Japanese, and Native Hawaiians in Hawaii.

Results

High plasma levels of C-peptide were statistically significantly associated with risk of colorectal adenoma [multivariate odds ratio (95% confidence interval) for increasing quartiles: 1.0, 0.91 (0.65-1.27), 1.21 (0.86-1.71), and 1.79 (1.23-2.60); P(trend) = 0.0002]. We also observed a stati

SUBMITTER: Le Marchand L 

PROVIDER: S-EPMC2882992 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature