Ontology highlight
ABSTRACT:
SUBMITTER: Onouchi Y
PROVIDER: S-EPMC2893807 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Human molecular genetics 20100427 14
Kawasaki disease (KD; OMIM 611775) is an acute vasculitis syndrome which predominantly affects small- and medium-sized arteries of infants and children. Epidemiological data suggest that host genetics underlie the disease pathogenesis. Here we report that multiple variants in the caspase-3 gene (CASP3) that are in linkage disequilibrium confer susceptibility to KD in both Japanese and US subjects of European ancestry. We found that a G to A substitution of one commonly associated SNP located in ...[more]