Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration.

ABSTRACT:

Study objectives

The main energy reserve of the brain is glycogen, which is almost exclusively localized in astrocytes. We previously reported that cerebral expression of certain genes related to glycogen metabolism changed following instrumental sleep deprivation in mice. Here, we extended our investigations to another set of genes related to glycogen and glucose metabolism. We also compared the effect of instrumentally and pharmacologically induced prolonged wakefulness, followed (or not) by 3 hours of sleep recovery, on the expression of genes related to brain energy metabolism.

Design

Sleep deprivation for 6-7 hours.

Setting

Animal sleep research laboratory.

Participants

Adults OF1 mice.

Interventions

Wakefulness was maintained by "gentle sleep depri

SUBMITTER: Petit JM 

PROVIDER: S-EPMC2894432 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature