Alternative splicing is frequent during early embryonic development in mouse.

ABSTRACT:

Background

Alternative splicing is known to increase the complexity of mammalian transcriptomes since nearly all mammalian genes express multiple pre-mRNA isoforms. However, our knowledge of the extent and function of alternative splicing in early embryonic development is based mainly on a few isolated examples. High throughput technologies now allow us to study genome-wide alternative splicing during mouse development.

Results

A genome-wide analysis of alternative isoform expression in embryonic day 8.5, 9.5 and 11.5 mouse embryos and placenta was carried out using a splicing-sensitive exon microarray. We show that alternative splicing and isoform expression is frequent across developmental stages and tissues, and is comparable in frequency to the variation in whole-transcr

SUBMITTER: Revil T 

PROVIDER: S-EPMC2898759 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature