Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis.

ABSTRACT:

Background

Two novel genetic polymorphisms on chromosome 6q23 are associated with susceptibility to rheumatoid arthritis (RA). Both polymorphisms (rs6920220 and rs10499194) reside in a region close to the gene encoding tumour necrosis factor alpha-induced protein 3 (TNFAIP3). TNFAIP3 is a negative regulator of NF-kappaB and is involved in inhibiting TNF-receptor-mediated signalling effects. Interestingly, the initial associations were detected in patients with longstanding RA. However, no association was found for rs10499194 in a Swedish cohort with early arthritis. This might be caused by over-representation of patients with severe disease in cohorts with longstanding RA.

Objective

To analyse the effect of the 6q23 region on the rate of joint destruction.

Methods

Fiv

SUBMITTER: Scherer HU 

PROVIDER: S-EPMC2927680 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature