Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis.

ABSTRACT:

Background

Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved.

Methods

We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech (AOS)/agrammatism (10 patients); AOS/no agrammatism (4 patients); no AOS/agrammatism (3 patients); no AOS/no agrammatism (7 patients). These groups were further characterized using a detailed neurolinguistic and neuropsychological battery. Parkinsonism was present in 3/10 patients in the AOS/agrammatism group. All patients in the no AOS/agrammatism group had mutations in the progranulin (GRN) gene, while 5/7 cases in the no AOS/no agramma

SUBMITTER: Rohrer JD 

PROVIDER: S-EPMC2931766 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature